Elite Manhattan drag queens Vida Boheme (Patrick Swayze) and Noxeema Jackson (Wesley Snipes) impress regional judges in competition, securing berths in the Nationals in Los Angeles. When the two meet pathetic drag novice Chi-Chi Rodriguez (John Leguizamo) — one of the losers that evening — the charmed Vida and Noxeema agree to take the hopeless youngster under their joined wing. Soon the three set off on a madcap road trip across America and struggle to make it to Los Angeles in time.